This completely revised and expanded reference provides comprehensive, single-source coverage of the latest toxicity testing requirements and methods for personal care products, industrial and agricultural chemicals, and consumer goods. Focusing on product safety techniques and regulatory requirements developed and instituted since the original edition was published a decade ago, the Second Edition of the Product Safety Evaluation Handbook contains a new chapter on toxicokinetic testing and modeling offers the latest solutions to common problems in testing and risk assessment supplies an updated bibliography and more than 1300 references—over 100 new to this edition—to facilitate further study presents recent data relevant and valid for the global market clarifies and evaluates novel program design hazards advises on the precise design, execution, and analysis of studies gives a new emphasis to an understanding of the physical properties of products furnishes up-to-the-minute information on collecting, tabulating, and comparing data establishes improved criteria for assessing laboratory competency and more!
The Product Safety Evaluation Handbook, Second Edition serves as a companion in the interactive, multidisciplinary process of defining and developing a data package for product safety evaluation programs, and meets the needs of toxicologists, pharmacologists, clinical and histopathologists, biochemists, industrial hygenists, product safety and laboratory managers, and advanced undergraduate and graduate students in these disciplines.
Preface to the Second Edition
Preface to the First Edition
Contributors
Chapter 1 : Defining the Objective : Product Safety Assessment Program Design and Scheduling Chapter 2 : Toxicology Information Sources and Their Use Chapter 3 : Acute Systemic Toxicity Testing Chapter 4 : Evaluating Products for Their Potential to Cause Dermal and Ocular Irritation and Corrosion Chapter 5 : Predicting Dermal Hypersensitivity Response Chapter 6 : Genetic Toxicology Testing Chapter 7 : Repeated-Dose Toxicity Studies Chapter 8 : Neuro and Behavioral Toxicology Testing Chapter 9 : Techniques for Evaluating Hazards of Inhaled Products Chapter 10 : Reproductive Hazards Chapter 11 : Developmental Toxicology Chapter 12 : Assessment and Modeling of the Biological Hazards of Combustion Products Chapter 13 : Practical Statistical Analysis Chapter 14 : Placing and Monitoring Testing at External Facilities Chapter 15 : Hazard and Risk Assessment Chapter 16 : Toxicokinetic Studies in the Commercial Development of Agricultural and Industrial Chemical Products